What does CREB stand for?
What does CREB mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: CREB.
We've found a total of 7 definitions for CREB:
cAMP Response Element Binding Protein
Cyclic-AMP Response Element Binding
Champion Parts, Inc.
Cairns Regional Electricity Board
Cyclicamp Response Element Binding
Clinical Research Ethics Board
CERN Reports Editorial Board
What does CREB mean?
- CREB is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements, thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: c-fos, the neurotrophin BDNF, tyrosine hydroxylase, and many neuropeptides. CREB is closely related in structure and function to CREM and ATF-1 proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain. CREB has been shown to be integral in the formation of spatial memory. In recent experiments it has been demonstrated that CREB may possess therapeutic potential for patients that have Alzheimer's disease.