What does PARL stand for?
What does PARL mean? This page is about the various possible meanings of the acronym, abbreviation or slang term: PARL.
What does PARL mean?
- Presenilins-associated rhomboid-like protein, mitochondrial is a protein that in humans is encoded by the PARL gene. It is a member of the rhomboid family of intramembrane serine proteases. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.