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| ASL | American Sign Language | |
| ASL | Advanced System of Languages | |
| ASL | American School in London | |
| ASL | Age, Sex, Location | |
| ASL | Aqua Syndrome Live | |
| ASL | Advanced Squad Leader | |
| ASL | ACPI Source Language | |
| ASL | Audiogenre Software, Ltd. | |
| ASL | Air Soft League | |
| ASL | Analytical Service Laboratories | |
| ASL | American Soccer League | |
| ASL | Average Shot Length | |
| ASL | Association for Symbolic Logic | |
| ASL | Anti-Saloon League | |
| ASL | Apache Software License | |
| ASL | Atlanta Sound and Lights Company | |
| ASL | Algebraic Specification Language | |
| ASL | Adjustable Sun Lounger | |
| ASL | Aussie Sports Leaders | |
| ASL | American Supportive Language | |
| ASL | Assessment of Student Learning | |
| ASL | Ambient Stress Level | |
| ASL | Applied Sciences Laboratory | |
| ASL | Adventure Scripting Language | |
| ASL | Above Sea Level |
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