| EPIC | Epicor Software | |
| EPIC | Equatorial Pacific Interocean Circulation | |
| EPIC | Eastern Pacific Investigation of Climate Processes | |
| EPIC | Eston Players In Concert | |
| EPIC | Exchange Price Information Code | |
| EPIC | East Pacific Investigation of Climate | |
| EPIC | Educational Process Improvement Committee | |
| EPIC | Explicitly Parallel Instruction Computing | |
| EPIC | Evangelizing Puppeteers In Christ | |
| EPIC | EPPL (Educational Policy, Planning, and Leadership) Program Interface Consortium | |
| EPIC | Encapsulated Protection Inside Clothing | |
| EPIC | Electronically Published Internet Connection | |
| EPIC | Excellent Performance In Communications | |
| EPIC | Exceptional People Impacting the Community | |
| EPIC | Electronic Proportional Injection Control | |
| EPIC | Excavation, Pipeline Inspection, and Construction | |
| EPIC | Elderly Pharmaceutical Insurance Coverage | |
| EPIC | Electric Powered Interurban Commuter | |
| EPIC | Experiencing Peace In Christ | |
| EPIC | Enhanced Programmable IRC II (Internet Relay Chat version 2) Client | |
| EPIC | Every Person Influences Children | |
| EPIC | Equipping People In Christ | |
| EPIC | Exclusively Parallel Instruction Computing | |
| EPIC | Electronic Purchasing In Cargill | |
| EPIC | Encountering Power In Christ |
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