| LESS | Logistics Execution Support System | |
| LESS | Laparo Endoscopic Single Site | |
| LESSON | Liberated European Sovereign State Opportunities Neverending | |
| LESSON | Little Energetic Stupid Sussy Over Negative | |
| LEST | Santiago de Compostela, S-Spain | |
| LEST | Large Earth-Based Solar Telescope | |
| LEST | Low End Systems and Technologies | |
| LESTD (CBER) | Laboratory of Enteric and Sexually Transmitted Diseases (CBER) | |
| LESU | Seo de Urgel, S-Spain | |
| LET | Light Equipment Transporter | |
| LET | Leticia, Colombia | |
| LET | Line Equipment Transfer | |
| LET | Lidocaine, Epinephrine and tetracaine (a topical anesthetic) | |
| LET | Lake Erie Transit | |
| LET | Lake Erie Transit | |
| LET | Linear Energy Transfer | |
| LET | Light Equipment Transport | |
| LET | LET statement as used in BASIC Programming Language to assign a value to a variable | |
| LeT | lashkar-e-taiba:a terrorist organization. | |
| LET | Ladies European Tour | |
| LET | Lashkar e Toiba | |
| LET | Lashkar E Taiba | |
| LET | Law Enforcement Technology | |
| LET | Leaving Early Today | |
| LET | L E T Les Enfants Terribles |
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