| OPEP | Oscillatory Positive Expiratory Pressure | |
| OPEP | Osteoporosis Prevention Exercise Protocol | |
| OPEP | Occupational Post Exposure Prophylaxis | |
| OPEP | Ottawa Psychiatry Enrichment Program | |
| OPEP | Office of Policy Evaluation and Planning | |
| OPEP | One Pion Exchange Potential | |
| OPEP | Office of Policy Evaluation Planning | |
| OPEQ | Ordinateurs Pour les Ecoles du Quebec | |
| OPER | Operation | |
| OPER | Operations, Operate, Operator | |
| OPER | Order Pay Earn Redeem | |
| OPER | Open Roadsters | |
| OPERA | Open Process Engine For Reliable Activities | |
| OPERA | Office of Policy for Extramural Research Administration | |
| OPERA | Option Portfolio for Emissions Reduction Assessment | |
| OPERA | Out of Pile Expulsion and Reentry Apparatus | |
| OPERA | Oscillation Project with Emulsion tRacking Apparatus | |
| OPERREQ | Operator Requests | |
| OPERRESP | OPERator RESPonse | |
| OPERS | Ohio Public Employees' Retirement System | |
| OPES | Open Pluggable Edge Services | |
| OPES | Orchard Park Elementary School | |
| OPES | Ohio's Principal Evaluation System | |
| OPES | Only Part of Each Specimen | |
| OPES | Oak Pointe Elementary School |
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