| SMIL | Synchronized Multimedia Integration Language | |
| SMIL | Suzuki Maruti India Limited | |
| SMIL | Sharda Motor Industries Limited | |
| SMIL | Synchronized Multimedia Integration Language | |
| SMILE | Swiss Market Index-Linked Issue | |
| SMILE | Subjective Multidimensional Interactive Laughter Evaluation | |
| SMILE | Skills More for Independent Living and Employment | |
| SMILE | Science and Math Investigative Learning Experiences | |
| SMILE | Solution Mapping Intelligent Learning Environment | |
| SMILE | Safety Magic In Law Enforcement | |
| SMILE | Support Meaningful Involvement Love and Education | |
| SMILE | Sensational Moms In Local Euclid | |
| SMILE | Stoney Middleton Interest Leisure Enterprise | |
| SMILE | Southwestern Michigan Interconnect for Learning Experience | |
| SMILE | Shared Moments In Living and Eating | |
| SMILE | Special Ministry In Lay Evangelism | |
| SMILE | See More Information Less Estimation | |
| SMILE | Sensory Motor Instructive Leadership Experience | |
| SMILE | Siteowners Making Internet Life Easier | |
| SMILE | Sustaining Mechanism and Initiative for Livelihood and Employment | |
| SMILE | Students Motivated In Literacy Education | |
| SMILE | Self Motivation In Lasting Endorphins | |
| SMILE | Students Making Individual Lives Easier | |
| SMILE | Surround Me In Love Eternal | |
| SMILE | Serving Many In Life Everyday |
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