What does TLR mean in Physiology?
This page is about the meanings of the acronym/abbreviation/shorthand TLR in the Medical field in general and in the Physiology terminology in particular.
Toll-Like Receptors
Submitted by agnm on May 29, 2012
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Definition
What does TLR mean?
- toll-like receptors
- Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have reached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Humans lack genes for TLR11, TLR12 and TLR13 and mice lack a functional gene for TLR10. TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10 are located on the cell membrane, whereas TLR3, TLR7, TLR8, and TLR9 are located in intracellular vesicles (because they are sensors of nucleic acids).TLRs received their name from their similarity to the protein coded by the toll gene.
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"TLR." Abbreviations.com. STANDS4 LLC, 2024. Web. 19 Apr. 2024. <https://www.abbreviations.com/term/1405837>.
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