What does SHM mean in Physiology?
This page is about the meanings of the acronym/abbreviation/shorthand SHM in the Medical field in general and in the Physiology terminology in particular.
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What does SHM mean?
- Somatic hypermutation
- Somatic hypermutation is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it. A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements and allows the immune system to adapt its response to new threats during the lifetime of an organism. Somatic hypermutation involves a programmed process of mutation affecting the variable regions of immunoglobulin genes. Unlike germline mutation, SHM affects only individual immune cells, and the mutations are not transmitted to offspring. Mistargeted somatic hypermutation is a likely mechanism in the development of B-cell lymphomas.