What does PARL mean in Animals?
This page is about the meanings of the acronym/abbreviation/shorthand PARL in the Miscellaneous field in general and in the Animals terminology in particular.
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What does PARL mean?
- Presenilins-associated rhomboid-like protein, mitochondrial is a protein that in humans is encoded by the PARL gene. It is a member of the rhomboid family of intramembrane serine proteases. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.