DUFF is an abbreviation for:

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Designated Ugly Fat Friend

Miscellaneous » Funnies

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Definition

What does DUFF mean?

duff(n.)
the buttocks or rump.

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"DUFF." Abbreviations.com. STANDS4 LLC, 2013. Web. 23 May 2013. <http://www.abbreviations.com/term/360900>.

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