What does CREB mean in Human Genome?

This page is about the meanings of the acronym/abbreviation/shorthand CREB in the Medical field in general and in the Human Genome terminology in particular.

cAMP Response Element Binding Protein

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Definition

What does CREB mean?

CREB
CREB is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements, thereby increasing or decreasing the transcription of the downstream genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene. Genes whose transcription is regulated by CREB include: c-fos, the neurotrophin BDNF, tyrosine hydroxylase, and many neuropeptides. CREB is closely related in structure and function to CREM and ATF-1 proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain. CREB has been shown to be integral in the formation of spatial memory. In recent experiments it has been demonstrated that CREB may possess therapeutic potential for patients that have Alzheimer's disease.

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"CREB." Abbreviations.com. STANDS4 LLC, 2014. Web. 19 Dec. 2014. <http://www.abbreviations.com/term/391087>.


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