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What does HLA-B27 stand for? 

What does HLA-B27 mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: HLA-B27.

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Human Leucocyte Antigen B27


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What does HLA-B27 mean?

Human Leukocyte Antigen B27 is a class I surface antigen encoded by the B locus in the major histocompatibility complex on chromosome 6 and presents antigenic peptides to T cells. HLA-B27 is strongly associated with ankylosing spondylitis, and other associated inflammatory diseases referred to "spondyloarthropathies". The prevalence of HLA-B27 varies markedly in the general population. For example, about 8% of Caucasians, 4% of North Africans, 2-9% of Chinese, and 0.1-0.5% of persons of Japanese descent possess this gene. In northern Scandinavia, 24% of people are HLA-B27 positive, while 1.8% have associated ankylosing spondylitis. A small group of people infected with HIV are able to remain symptom-free for many years without medication. These "HIV controllers" appear to be slightly more common among people who are HLA-B27 positive.

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"HLA-B27." Abbreviations.com. STANDS4 LLC, 2019. Web. 25 Aug. 2019. <https://www.abbreviations.com/HLA-B27>.

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