| DEFBTN | Default Button | |
| DEFC | DeWitt Evangelical Free Church | |
| DEFC | Dixhills Evangelical Free Church | |
| DEFC | DeForest Evangelical Free Church | |
| DEFC | Doncaster East Football Club | |
| DEFC | Digitizing Early Farming Cultures | |
| DEFC | Digitizing Early Farming Cultures | |
| DEFC | Doncaster East Football Club | |
| DEFC | Disaster Emergency Fund Code | |
| DEFC | DeWitt Evangelical Free Church | |
| DEFC | Dixhills Evangelical Free Church | |
| DEFC | DeForest Evangelical Free Church | |
| DEFC | Documentary and Experimental Film Center | |
| DEFC | Direct ethanol fuel cells | |
| DEFC | Distributed Extended Forward Checking | |
| DEFC | Dry Eye Flow Chart | |
| DEFC | Direct Ethanol Fuel Cell | |
| DEFC | Direct-Ethanol Fuel Cell | |
| DEFCON | Defense Readiness Condition | |
| DEFE | Differential Expression Feature Extraction | |
| DEFE | Driver Emotion Facial Expression | |
| DEFEAT | Diet Exercise Family Education Attitude and Thriving | |
| DEFEAT | Diet Exercise Family Education Attitude and Thriving | |
| defen | defence | |
| DEFEND | Defiance at the End |
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