| DEFOG | Discrete Enrichment of Functionally Organized Genes | |
| DEFOMA | Debian Font Manager | |
| DEFRA | Department for Environment, Food and Rural Affairs | |
| DEFRA | Department for Environment, Food, and Rural Affairs | |
| DEFRA | Do Everything Farmers Representatives Ask | |
| DEFRA | Department for Environment Food and Rural Affairs | |
| DEFRA | Department for Environment Food Rural Affairs | |
| DEFRA | Department for Environment Food and Rural Affaires | |
| DEFRA | Department Of Eradicating Farming And Real Agriculture | |
| DEFRA | Department for Environment, Food, and Rural Affairs | |
| DEFRA | Department for Environment, Food, and Rural Affairs | |
| DEFRA | Department for Environment, Food, and Rural Affairs ( U K: successor to MAFF) | |
| DEFRAG | optomize a disk drive (be careful) | |
| DEFRLY | Defogger Relay | |
| DEFs | Data Exchange Formats | |
| DEFS | Dutch Exertion Fatigue Scale | |
| DEFS | Direct Applied Exterior Finishing System | |
| DEFS | Deschutes Estuary Feasibility Study | |
| DEFS | Detailed Evaluation of Facial Symmetry | |
| DEFS | Den Europeiske Faglige Samorganisasjon | |
| DEFSMAC | DEFense Special Missile and Astronautics Center | |
| DEFSMAC | DEFense Special Missile and Astronautics Center | |
| DEFT | Dress Education Food Treatment | |
| DEFT | Direct Electronic Funds Transfer | |
| DEFT | Disbursement Electronic Fund Transfer |
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