| DEFMAN | Definitions Manager | |
| DEFN | Definition | |
| DEFO | Definitely | |
| DEFO | Definitely | |
| DEFO | Definitely | |
| DEFO | Definitely | |
| DEFO | Developing ESNI For OpenSSL | |
| DEFO | Dynamic Elastomeric Fabric Orthosis | |
| DEFO | Direct Entry First Officer | |
| DEFO | Dynamic Elastomeric Fabric Orthoses | |
| DEFO | Declarative and Expressive Forwarding Optimizer | |
| DEFO | Developing ECH For OpenSSL | |
| DEFOG | Discrete Enrichment of Functionally Organized Genes | |
| DEFOMA | Debian Font Manager | |
| DEFRA | Department for Environment, Food, and Rural Affairs ( U K: successor to MAFF) | |
| DEFRA | Department for Environment, Food, and Rural Affairs | |
| DEFRA | Department Of Eradicating Farming And Real Agriculture | |
| DEFRA | Department for Environment, Food, and Rural Affairs | |
| DEFRA | Department for Environment, Food, and Rural Affairs | |
| DEFRA | Department for Environment, Food and Rural Affairs | |
| DEFRA | Department for Environment Food and Rural Affairs | |
| DEFRA | Department for Environment Food Rural Affairs | |
| DEFRA | Do Everything Farmers Representatives Ask | |
| DEFRA | Department for Environment Food and Rural Affaires | |
| DEFRAG | optomize a disk drive (be careful) |
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