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| HOBIT | Hyperbaric Oxygen Brain Injury Treatment | |
| HOBIT | Hybrid Optical Based Inertial Tracker | |
| HOBO | Helping Our Brother's Out | |
| HOBO | Helping Our Brothers Out | |
| HOBO | Help Our Brothers Out | |
| HOBO | Homing Bomb | |
| HOBO | Home Owners Bargain Outlet | |
| HOBO | Home Owners Builders Outlet | |
| HOBO | High Output Brushless Outrunner | |
| HOBO | Helping Other Brothers Out | |
| HOBO | Hispanics Over Black Orchestration | |
| HOBO | Helping Others Build Opportunity | |
| HOBO | Helping Others Bring Opportunity… | |
| HOBO | Home Owners Bargain Outlets | |
| HOBO | HOmeward BOund | |
| HOBO | Household Order Bin Operations | |
| HOBO | Help Other Brothers Out | |
| HOBO | Hamilton Oldtimers Baseball Organization | |
| HOBO | Home Office Business Office | |
| HOBO | House Of Blues Orlando | |
| HOBO | High On Body Odor | |
| HOBO | Helping Others Before Ourselves | |
| HOBOE | Head-of-Bed Optimization of Elevation | |
| HOBOE | Head Of Bed Optimization of Elevation | |
| HOBOS | HOming BOmb System |
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