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| IOU | Ile Ouen, New Caledonia | |
| IOU | Inform Open Unite | |
| IOU | Innovative Original Unique | |
| IOU | Is Owed Unto .... | |
| IOU | Intensive Therapy Observation Unit. | |
| IOU | Input/Output Unit | |
| IOU | Internal Office Use | |
| IOU | Inside Our Universe | |
| IOU | Islamic Online University | |
| IOU | Input Output Unit | |
| IOU | IOS on Unix | |
| IOU | Iodine Oxygen and Uranium | |
| IOU | Independent Operating Unit | |
| IOU | Illinois Owes Us | |
| IOU | I Owe You | |
| IOU | Images of Us | |
| IOU | Interdependent Occupational Unit | |
| IOU | Intersection over Union | |
| IOU | Investor Owned Utility | |
| IOU | Integrated Optics for Undergraduates | |
| IOU | Inward Outward and Upward | |
| IOU | Improved Outback Upgrade | |
| IOU | Idle Online Universe | |
| IOU | International Open University | |
| IOU | International Open University |
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