| OPERA | Out of Pile Expulsion and Reentry Apparatus | |
| OPERREQ | Operator Requests | |
| OPERRESP | OPERator RESPonse | |
| OPERS | Ohio Public Employees' Retirement System | |
| OPES | Officine Precisione E Stampaggio | |
| OPES | Open Pluggable Edge Services | |
| OPES | Open Pluggable Edge Services | |
| OPES | Orchard Park Elementary School | |
| OPES | Oak Pointe Elementary School | |
| OPES | Oak Point Elementary School | |
| OPES | Ohio's Principal Evaluation System | |
| OPES | Only Part of Each Specimen | |
| OPEST | Oil Protection of Emissions Systems Test | |
| OPET | Office for Professional Education and Technology | |
| OPET | Organisations for the Promotion of Energy Technologies | |
| OPET | Oyster Pond Environmental Trust | |
| OPET | Office for Professional Education and Technology | |
| OPET | Outdoor Power Equipment Technician | |
| OPET | Office of Professionalism Ethics and Training | |
| OPET | Optical Positron Emission Tomography | |
| Opetec | Open Technology | |
| OPEX | OPerational EXpenditure | |
| OPEX | Operational Excellence | |
| OPEX | Operating Expenses | |
| OPF | OpaLocka Airport, Miami, Florida |
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