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Acronyms that contain the term tirap
What does tirap mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: tirap.
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TIQ, TIQA, TIQFF, TIR, TIRA, TIRAS, TIRB, TIRC, TIRCHA, TIRD
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What does tirap mean?
- TIRAP
- TIRAP is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
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