What does TRIF mean in Unclassified?

This page is about the meanings of the acronym/abbreviation/shorthand TRIF in the Miscellaneous field in general and in the Unclassified terminology in particular.

Tulsa Road Information Feed

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Definition

What does TRIF mean?

TRIF
TIR-domain-containing adapter-inducing interferon-β is an adapter in responding to activation of toll-like receptors. It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. Toll-like receptors recognize specific components of microbial invaders and activate an immune response to these pathogens. After these receptors recognize highly-conserved pathogenic patterns, a downstream signaling cascade is activated in order to stimulate the release of inflammatory cytokines and chemokines as well as to upregulate the expression of immune cells. All TLRs have a TIR domain that initiates the signaling cascade through TIR adapters. Adapters are platforms that organize downstream signaling cascades leading to a specific cellular response after exposure to a given pathogen.

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"TRIF." Abbreviations.com. STANDS4 LLC, 2020. Web. 1 Apr. 2020. <https://www.abbreviations.com/term/1454079>.

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