What does CREB mean in Unclassified?

This page is about the meanings of the acronym/abbreviation/shorthand CREB in the Miscellaneous field in general and in the Unclassified terminology in particular.

CAMP Response Element Binding

Miscellaneous » Unclassified

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Submitted by S4Bot on November 7, 2020

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Definition

What does CREB mean?

CREB
CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.Genes whose transcription is regulated by CREB include: c-fos, BDNF, tyrosine hydroxylase, numerous neuropeptides (such as somatostatin, enkephalin, VGF, corticotropin-releasing hormone), and genes involved in the mammalian circadian clock (PER1, PER2).CREB is closely related in structure and function to CREM (cAMP response element modulator) and ATF-1 (activating transcription factor-1) proteins. CREB proteins are expressed in many animals, including humans. CREB has a well-documented role in neuronal plasticity and long-term memory formation in the brain and has been shown to be integral in the formation of spatial memory. CREB downregulation is implicated in the pathology of Alzheimer's disease and increasing the expression of CREB is being considered as a possible therapeutic target for Alzheimer's disease. CREB also has a role in photoentrainment in mammals.

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"CREB." Abbreviations.com. STANDS4 LLC, 2024. Web. 28 Mar. 2024. <https://www.abbreviations.com/term/2272539>.

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