What does CML mean in Physiology?

This page is about the meanings of the acronym/abbreviation/shorthand CML in the Medical field in general and in the Physiology terminology in particular.

Chronic Myelogenous Leukemia

Medical » Physiology

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Definition

What does CML mean?

Chronic myelogenous leukemia
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which a proliferation of mature granulocytes (neutrophils, eosinophils and basophils) and their precursors is found. It is a type of myeloproliferative neoplasm associated with a characteristic chromosomal translocation called the Philadelphia chromosome. CML is largely treated with targeted drugs called tyrosine-kinase inhibitors (TKIs) which have led to dramatically improved long-term survival rates since 2001. These drugs have revolutionized treatment of this disease and allow most patients to have a good quality of life when compared to the former chemotherapy drugs. In Western countries, CML accounts for 15–25% of all adult leukemias and 14% of leukemias overall (including the pediatric population, where CML is less common).

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"CML." Abbreviations.com. STANDS4 LLC, 2024. Web. 29 Mar. 2024. <https://www.abbreviations.com/term/37436>.

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