What does MSI mean in NASA?

This page is about the meanings of the acronym/abbreviation/shorthand MSI in the Governmental field in general and in the NASA terminology in particular.

MicroSatellite Instability

Governmental » NASA

Translation

Find a translation for MicroSatellite Instability in other languages:

Select another language:

  • - Select -
  • Chinese - Simplified 简体中文 (Chinese - Simplified)
  • Chinese - Traditional 繁體中文 (Chinese - Traditional)
  • Spanish Español (Spanish)
  • Esperanto Esperanto (Esperanto)
  • Japanese 日本語 (Japanese)
  • Portuguese Português (Portuguese)
  • German Deutsch (German)
  • Arabic العربية (Arabic)
  • French Français (French)
  • Russian Русский (Russian)
  • Kannada ಕನ್ನಡ (Kannada)
  • Korean 한국어 (Korean)
  • Hebrew עברית (Hebrew)
  • Ukrainian Український (Ukrainian)
  • Urdu اردو (Urdu)
  • Hungarian Magyar (Hungarian)
  • Hindi मानक हिन्दी (Hindi)
  • Indonesian Indonesia (Indonesian)
  • Italian Italiano (Italian)
  • Tamil தமிழ் (Tamil)
  • Turkish Türkçe (Turkish)
  • Telugu తెలుగు (Telugu)
  • Thai ภาษาไทย (Thai)
  • Vietnamese Tiếng Việt (Vietnamese)
  • Czech Čeština (Czech)
  • Polish Polski (Polish)
  • Indonesian Bahasa Indonesia (Indonesian)
  • Romanian Românește (Romanian)
  • Dutch Nederlands (Dutch)
  • Greek Ελληνικά (Greek)
  • Latin Latinum (Latin)
  • Swedish Svenska (Swedish)
  • Danish Dansk (Danish)
  • Finnish Suomi (Finnish)
  • Persian فارسی (Persian)
  • Yiddish ייִדיש (Yiddish)
  • Armenian հայերեն (Armenian)
  • Norwegian Norsk (Norwegian)
  • English English (English)

Definition

What does MSI mean?

Microsatellite instability
Microsatellite instability is the condition of genetic hypermutability that results from impaired DNA Mismatch Repair. In other words, MSI is the phenotypic evidence that MMR isn't functioning normally. DNA MMR corrects errors that spontaneously occur during DNA replication like single base mismatches or short insertions and deletions. The proteins involved in MMR form a complex that binds to the mismatch, identifies the correct strand of DNA, then subsequently excises the error and repairs the mismatch. Cells with abnormally functioning MMR tend to accumulate errors rather than correcting those errors. As a result gene sequences are not preserved faithfully through DNA replication, and novel Microsatellites fragments are created. Microsatellite instability is detected by PCR based assays that reveal these novel microsatellites. There are two mechanisms that cause impaired MMR: 1. MMR gene mutation that results in a malfunctioning gene product 2. MMR gene product underproduction Microsatellite instability detects that MMR is functionally impaired, but does not imply the mechanism by which it is impaired. MSI-PCR can be used as a less expensive screening tool for MMR gene mutations that are confirmed by gene sequencing.

see more »

Popularity rank by frequency of use

How popular is MSI among other acronyms?

MSI#1#883#12977

Embed

Discuss this MSI abbreviation with the community:

Citation

Use the citation below to add this abbreviation to your bibliography:

Style:MLAChicagoAPA

"MSI." Abbreviations.com. STANDS4 LLC, 2019. Web. 19 Oct. 2019. <https://www.abbreviations.com/term/376799>.

Free, no signup required:

Add to Chrome

Get instant explanation for any acronym or abbreviation that hits you anywhere on the web!

Free, no signup required:

Add to Firefox

Get instant explanation for any acronym or abbreviation that hits you anywhere on the web!