What does COMT mean in Laboratory?

This page is about the meanings of the acronym/abbreviation/shorthand COMT in the Medical field in general and in the Laboratory terminology in particular.

Catechol-O-MethylTransferase

Medical » Laboratory

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Submitted by paul8539 on December 23, 2009

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Definition

What does COMT mean?

comt
Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957.

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