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| MDE | Major Depressive Episode | |
| MDE | Mass Deviation Effect | |
| MDE | Modelos De Elevaci | |
| MDE | Manual Data Entry | |
| MDE | Most Disappointing Effort | |
| MDE | Market Development Engineering | |
| MDE | Major Design Element | |
| MDE | Mission Dependent Equipment | |
| MDE | Mission Dependent Experiment | |
| MDE | Modular Display Electronics | |
| MDE | Major Depressive Episode | |
| MDE | Maximum Design Earthquake | |
| MDE | Minnesota Department of Education | |
| MDE | Managing Data Efficiently | |
| MDE | Million Dollar Extreme | |
| MDE | Minimum Detectable Effect | |
| MDE | Media Disk Encryption | |
| MDE | Maritime Data Engine | |
| MDE | Masters Direct Entry | |
| MDE | Motor Drive End | |
| MDE | Model Driven Engineering | |
| MDE | Master in Design Engineering | |
| MDE | My Disney Experience | |
| MDE | Mitsubishi Design Europe | |
| MDE | Medium Diesel Engine |
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