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| OME | Online Metadata Editor | |
| OME | Open Modeling Environment | |
| OME | Office Message Encryption | |
| OME | Open Manage Essentials | |
| OME | Online Marketing Executive | |
| OME | Ontario Ministry of Education | |
| OME | Office of Mediated Education | |
| OME | Otitis Media with Effusion | |
| OME | Osteopathic Medical Education | |
| OME | Otitis Media with Effusion | |
| OME | Office of the Medical Examiner | |
| OME | Orion Main Engine | |
| OME | Orbital Maneuvering Engine | |
| OME | Orbiter Main Engine | |
| OME | Offline Message Editor | |
| OME | Osasun Mentalaren Elkartea | |
| OME | Online Meet Entry | |
| OME | Open Microscopy Environment | |
| OME | Online Meet Entries | |
| OME | Observatoire Méditerranéen de l'Energie | |
| OME | Oh many Edwards | |
| OME | Oh My Emppu | |
| OME | Own My Edward | |
| OME | Order of Magnitude Estimate | |
| OME | One More Edward |
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