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| D3D | Direct Three Dimensional | |
| D3DRM | d3d Retained Mode | |
| D3EA | Dual Dynamometer Differential Effectiveness Analysis | |
| D4 | 4-Sided Dice | |
| D4 | Digital channel bank, Fourth generation | |
| D48 | Dundee Flying Club Airport, Dundee, New York USA | |
| D4C | Driving for Change | |
| D4C | Dirty Deeds Done Dirt Cheap | |
| D4D | Direct for Diesel | |
| D4D | Drive for Diversity | |
| D4H | Decisions 4 Heroes | |
| D4L | Drive for Life | |
| D4MB | Die For My B*tch | |
| D4P | Double Four Patch | |
| D4Q | Digital For Quality | |
| D4S | Direct Injection Four Stroke Superior Version | |
| d4T | Stavudine | |
| d4T | tavudine | |
| d4T | stavudine | |
| D4W | Down for Whatever | |
| D4X | Download Manager for X | |
| D5 | Destructive-size scale | |
| D5 | 5% Dextrose | |
| D5 | Fifth Coast Guard District | |
| D5 1/2NS | Dextrose 5% in 0.45% sodium chloride injection |
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