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| HPE | Hope Vale, Queensland, Australia | |
| HPE | Health Promotion Education | |
| HPE | High Performance Environment | |
| HPE | Health Promotion England (abolished, date unknown) | |
| HPE | hepatoportoenterostomy | |
| HPE | Higher Professional Education | |
| HPE | histopathological examination | |
| HPE | holoprosencephaly | |
| HPE | hydrostatic pulmonary (o)edema | |
| HPE | Hypericum perforatum extract | |
| HPE | Human Performance Engineering | |
| HPE | High Potential Elements | |
| HPE | Hewlett Packard Enterprise | |
| HPE | Highland Park Elementary | |
| HPE | Hattrick Press Editor | |
| HPE | High Performance and Excellence | |
| HPE | High Performance Executive | |
| HPE | Helping People Everywhere | |
| HPE | Hennessey Performance Engine | |
| HPE | Human Post Effects | |
| HPE | Honoring Past Experience | |
| HPE | Health and People Exercising | |
| HPE | HTTP Parse Error | |
| HPE | Health Professional Education | |
| HPE | Health Professional Education |
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