| ISY | International School Year | |
| ISYA | International School for Young Astronomers | |
| ISYA | International School for Young Astronomers | |
| ISYA | International Schools for Young Astronomers | |
| ISYA | International Schools for Young Astronomers | |
| ISYE | School of Industrial and Systems Engineering | |
| ISYEP | Inter State Youth Exchange Programmes | |
| ISYEP | In School Youth Employment Program | |
| ISYEP | In School Youth Employment Program | |
| ISYEP | In School Youth Employment Program | |
| ISYF | International Sikh Youth Federation | |
| ISYF | International Sikh Youth Federation | |
| ISYF | International Sikh Youth Federation | |
| ISYMFS | It’s Still Your Mother Frackin Set | |
| ISYMFS | It's Still Your Mothaf***in' Set | |
| ISYMFS | I See You Mother F***kers Staring | |
| ISYN | I Stuff You Not | |
| ISYN | I Saw Your Nanny | |
| ISYNC | Injection Synchronizing Sensor | |
| ISYOTOS | I’ll See You On The Other Side | |
| ISYP | International Student Young Pugwash | |
| ISYP | International Student Young Pugwash | |
| ISYR | Islamic Society of York Region | |
| ISYR | Islamic Society of York Region | |
| ISYR | Islamic Society of York Region |
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