| LOSD | Ludington Outdoor Social District | |
| LOSE | Let's Omit Superfluous Expenses | |
| LOSE | Let's Omit Superfluous Expenses | |
| LOSE | Lineage Online Server Emulator | |
| LOSE | Lack Of Sustained Effort | |
| LOSE | League Of Super Evil | |
| LOSE | Lightweight Oxygen Swimmers Equipment | |
| LOSER | Lovers Of Sodomy Embrace Rhodes | |
| LOSER | Legions Of Self-Deluded Elitist Retards | |
| LOSER | Lodge Of Superior Entities (that) Rendered | |
| LOSER | Latest Overweighted Super Edible Rockstar | |
| LOSER | Loose Organization of Surreal Ethereal Realists | |
| LOSER | Like Officially Super Extreme Rackets | |
| LOSER | Laughing Over Something Extra Retarded | |
| LOSER | Lots Of Salsa and Extra Rice | |
| LOSH | Legion of Super Heroes | |
| LOSH | Labor Occupational Safety and Health | |
| LOSH | London Occupational Safety and Health | |
| LOSHI | Latino Occupational Safety and Health Initiative | |
| LOSIM | Low Observable Simulation | |
| LOSJ | St. Johann-Pongau Heliport, S-Austria | |
| LOSK | Koppl, S-Austria | |
| LOSL | Salzburg (LKH) Heliport, S-Austria | |
| LOSL | London Ontario Soccer League | |
| LOSL | Lake Ontario St Lawrence |
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