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| OSF | One Step Further | |
| OSF | Open System Foundation | |
| OSF | Open Stack Foundation | |
| OSF | Open Security Framework | |
| OSF | Ordinateurs Sans Frontieres | |
| OSF | Optimal Solutions Found | |
| OSF | Old Style Figures | |
| OSF | Operational Support Facility | |
| OSF | Operational Support Facility ( Orlando) | |
| OSF | Open Software Foundation | |
| OSF | Object Strike Force | |
| OSF | Observed Support Frequency | |
| OSF | On Scene Forces | |
| OSF | Office of Space Flight | |
| OSF | Ordnance Storage Facility | |
| OSF | Open Software Foundation | |
| OSF | Operation Support Facility | |
| OSF | Oregon Shakespeare Festival | |
| OSF | Order of Saint Francis | |
| OSF | Order Of St Francis | |
| OSF | Franciscan Sisters (Allegany) | |
| OSF | sisters of St. Francis of Philadelphia | |
| OSF | Omaha Schools Foundation | |
| OSF | Open Science Framework | |
| OSF | Our Soccer Field |
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