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| OSI | Orthopaedic Specialty Institute | |
| OSI | Orthopaedic Surgical Institute | |
| OSI | Office of Superintendent of Insurance | |
| OSI | Office of the Superintendent of Insurance | |
| OSI | Operation Serve International | |
| OSI | Only Safe Internet | |
| OSI | Ordnance Survey Ireland | |
| OSI | Open Systems Interconnection | |
| OSI | Open Source Initiative | |
| OSI | Overflow Stack Immediate | |
| OSI | Open Source India | |
| OSI | Open Society Institute | |
| OSI | Office Of Supernatural Investigation | |
| OSI | Office of Scientific Investigation | |
| OSI | Open Systems Interconnection | |
| OSI | Office Of Strategic Intelligence | |
| OSI | Operational Subsystem Interface | |
| OSI | Open Systems Interconnection | |
| OSI | Open System Interconnection | |
| OSI | Open Source Institute | |
| OSI | Orthopaedic Specialty Institute | |
| OSI | Orthopaedic Surgical Institute | |
| OSI | Oxford Sciences Innovation | |
| OSI | OSI Software Inc | |
| OSI | Office of Student Involvement |
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