| OPEN | Organization of Pakistani Entrepreneurs of North | |
| OPEN | Open Protocol Enhanced Network | |
| OPEN | Object Oriented Process Environment and Notation | |
| OPENAL | Open Audio Library | |
| OPENCV | Open Source Computer Vision Library | |
| OPeNDAP | Open-source Project for a Network Data Access Protocol | |
| OPENDAP | Open Source Project for Network Data Access Protocol | |
| OPENGL | Open Graphics Library | |
| OPENITP | Open Internet Tools Project | |
| OPENMG | Open Magic Gate | |
| OPENMP | Open Multi Processing | |
| OPENSIA | OPEN / SIA | |
| OPENU | The Open University | |
| OPEP | Organización de Países Exportadores de Petróleo | |
| OPEP | Organisation des Pays Exportateurs de Pétrole | |
| OPEP | Office of Program Evaluation and Performance | |
| OPEP | Oscillating Positive Expiratory Pressure | |
| OPEP | Optometric Practice Enhancement Program | |
| OPEP | Organization of Parent Education Programs | |
| OPEP | Organização dos Países Exportadores de Petróleo | |
| OPEP | Ontario Pesticide Education Program | |
| OPEP | Operations Production Enterprises and Project | |
| OPEP | Organització de Països Exportadors de Petroli | |
| OPEP | Oil Pollution Emergency Plans | |
| OPEP | Organization of Parenting Education Programs |
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