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Acronyms that contain the term comt
What does comt mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: comt.
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COMSUBPAC, COMSUPNAVFOR, COMSWARE, COMSY, COMSY ENS, COMTA, COMTAC, COMTEL, COMU, COMURES
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What does comt mean?
- comt
- Catechol-O-methyltransferase (COMT; EC 2.1.1.6) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-O-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957.
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