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Acronyms that contain the term TRIF
What does TRIF mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: TRIF.
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TRID, TRIDENTCOM, TRIE, TRIEC, TRIES, TRIFR, Trig, TRIGA, TRIGS, TRIH
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What does TRIF mean?
- TRIF
- TIR-domain-containing adapter-inducing interferon-β (TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter.Toll-like receptors (TLRs) recognize specific components of microbial invaders and activate an immune response to these pathogens. After these receptors recognize highly conserved pathogenic patterns, a downstream signaling cascade is activated in order to stimulate the release of inflammatory cytokines and chemokines as well as to upregulate the expression of immune cells. All TLRs have a TIR domain that initiates the signaling cascade through TIR adapters. Adapters are platforms that organize downstream signaling cascades leading to a specific cellular response after exposure to a given pathogen.
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