What does SHM mean in Physiology?
This page is about the meanings of the acronym/abbreviation/shorthand SHM in the Medical field in general and in the Physiology terminology in particular.
somatic hypermutation
Submitted by agnm on June 6, 2012
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Definition
What does SHM mean?
- Somatic hypermutation
- Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes), as seen during class switching. A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements (antigens) and allows the immune system to adapt its response to new threats during the lifetime of an organism. Somatic hypermutation involves a programmed process of mutation affecting the variable regions of immunoglobulin genes. Unlike germline mutation, SHM affects only an organism's individual immune cells, and the mutations are not transmitted to the organism's offspring. Because this mechanism is merely selective and not precisely targeted, somatic hypermutation has been strongly implicated in the development of B-cell lymphomas and many other cancers.
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"SHM." Abbreviations.com. STANDS4 LLC, 2024. Web. 5 May 2024. <https://www.abbreviations.com/term/1406453>.
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