What does PARL mean in Unclassified?

This page is about the meanings of the acronym/abbreviation/shorthand PARL in the Miscellaneous field in general and in the Unclassified terminology in particular.

Presenilin Associated Rhomboid Like

Miscellaneous » Unclassified

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Definition

What does PARL mean?

PARL
Presenilins-associated rhomboid-like protein, mitochondrial is a protein that in humans is encoded by the PARL gene. It is a member of the rhomboid family of intramembrane serine proteases. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.

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"PARL." Abbreviations.com. STANDS4 LLC, 2022. Web. 17 Jan. 2022. <https://www.abbreviations.com/term/1476611>.

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