| IRIS | Intelligent Retinal Imaging Systems | |
| IRIS | It Really Is Simple | |
| IRIS | Intelligent Roadway Information System | |
| IRIS | Institutional Research Information Solution | |
| IRIS | Increasing Retention and Inclusion in STEM | |
| IRIS | Inclusion Respecting Identity and Sexuality | |
| IRIS | Innovative Response to Improve Safety | |
| IRIS | Incident Reporting Investigation System | |
| IRIS | Iowa Resource for International Service | |
| IRIS | Integrated Road Information System | |
| IRIS | Inertia Resonance Induction System | |
| IRIS | Independent Removable Information System | |
| IRIS | Information Relayed Instantly From the Source | |
| IRIS | Integrated Romanian Information Systems | |
| IRIS | Internet Registry Information Service | |
| IRIS | Infrastructure Recipient Information System | |
| IRIS | Infrastructure Recipient Information System | |
| IRIS | Infrastructure Recipient Information System | |
| IRIS | Infrastructure Recipient Information System | |
| IRIS | Integrated Retrieval Information System | |
| IRIS | Integrated Retrieval Information System | |
| IRIS | Integrated Retrieval Information System | |
| IRIS | Immigrant Reception and Information Services | |
| IRIS | Information Returns Intake System | |
| IRIS | Integration of Remote Information Systems |
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