| IRIS | Interactive Rendering and Image Segmentation | |
| IRIS | Infrastructure for Resilient Internet Systems | |
| IRIS | Ideas Responsibility Initiative And Service | |
| IRIS | Inland Revenue Information System | |
| IRIS | Inter-Religiousraat In Suriname | |
| IRIS | Innovative Rheological Interactive Software | |
| IRIS | Ivanhoe Reading Intervention Scheme | |
| IRIS | International Renal Interest Society | |
| IRIS | Intelligent Room Illumination Sensor | |
| IRIS | Image Recognition Integrated Systems | |
| IRIS | Innovative, Resourceful, Inspired, and Strategic | |
| IRIS | Image Retrieval Identification System | |
| IRIS | Individual Requirements Intelligent Solutions | |
| IRIS | Industry Resource Internet Supervision | |
| IRIS | Integrated Road Information System | |
| IRIS | Instructional Resource Information System | |
| IRIS | Intelligent Rotation In Space | |
| IRIS | Integrated Radiation Information System | |
| IRIS | Integrated Romanian Information System | |
| IRIS | Integrated Resource Information System | |
| IRIS | Information Regarding Israel Security | |
| IRIS | Incident Resolution Information System | |
| IRIS | Internal Revenue Information Services | |
| IRIS | International Reactor Innovative and Secure | |
| IRIS | Iraq Resource Information Site |
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