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| OPL | Oklahoma Premier League | |
| OPL | Operator Performance Laboratory | |
| OPL | Old Princeton Landing | |
| OPL | Oceanic Pro League | |
| OPL | Old Persian Lady | |
| OPL | Optimized Packaging Line | |
| OPL | Open PS2 Loader | |
| OPL | One Point Loss | |
| OPL | Out-migration Population Loss | |
| OPL | Other Party Liability | |
| OPL | Object Per Line | |
| OPL | Otolaryngology Physicians of Lancaster | |
| OPL | Optimum Performance Level | |
| OPL | OSHPD Preapproved Laboratory | |
| OPL | Open Part Library | |
| OPL | Ohio Prospects League | |
| OPL | Outside Port Limit | |
| OPL | Optomized Pulsed Light | |
| OPL | On Premise Laundry | |
| OPL | Overpressure Protection Limit | |
| OPL | Oil Pressure Low | |
| OPL | Oil Pressure Light | |
| OPL | Open Publication License | |
| OPL | Open Content License | |
| OPL | Open Programming Language |
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