| OTIS | Offender Tracking Information System | |
| OTIS | Online Teacher Information System | |
| OTIS | Organization of Teratology Information Specialists | |
| Otis | Only The Illuminati Survives | |
| OTIS | Optimal Traveling Independent Space | |
| OTIS | Optical Transpose Interconnection System | |
| OTIS | Occurrence Tracking Information System | |
| OTIS | Only The Illuminati Succeed | |
| OTIS | Our Time Is Short | |
| OTIS | Organ Transplant Information System | |
| OTIS | Online Tracking Information System | |
| OTIS | On Time In School | |
| OTIS | Operations Terminal Information System | |
| OTIS | Office of Transportation Infrastructure and Sustainability | |
| OTIS | Optimal Thermal Interpolation System | |
| OTIS | Online Transportation Information System | |
| OTIS | Online Technology and Instructional Sessions | |
| OTIS | Outstanding Technology Innovative and Service | |
| OTIS | Outside The Inner Sanctum | |
| OTIS | Optical Thermal Imaging System | |
| OTIS | Only The Illuminati Stands | |
| OTIS | Overhead Travel Information System | |
| OTIS | Online Transportation Information System | |
| OTIS | Online Travel Information System | |
| OTIS | Online Touring Information System |
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