| UPLA | Urban Partners Los Angeles | |
| UPLB | University of the Philippines Los Baños | |
| UPLC | Upland Energy Corporation | |
| UPLC | Ultra Performance Liquid Chromatography | |
| UPLE | Ubiquitous Personal Learning Environment | |
| UPLE | Universidad por la Emancipación | |
| UPLE | Ultrasound Point Localization Error | |
| UPLE | Ultrafiltered Pig Leukocyte Extract | |
| UPLF | Universal Proutist Labour Federation | |
| UPLF | Unique Premier League Football | |
| UPLF | University of the Philippines Lingua Franca | |
| UPLF | Union Professionnelle des Logopèdes Francophones | |
| UPLF | Unity Plus LED Flashlight | |
| UPLF | United People Liberation Front | |
| UPLF | United Peoples Liberation Front | |
| UPLH | Unaccompanied Personnel Leased Housing | |
| UPLI | Urgences Psychiatriques De Liaisons Intersectorielles | |
| UPLI | United Poets Laureate International | |
| UPLI | Unite Psychiatrique De Liaison Intersectorielle | |
| UPLI | Uniti per le imprese | |
| UPLI | Unione Produttori Latte Italiani | |
| UPLIFT | Using Practice and Learning to Increase Favorable Thoughts | |
| UPLIFT | Universal Peace and Love In a Festival of Transformation | |
| UPLIFT | Universal Peace Love In a Festival of Transformation | |
| UPLIFT | Universal Platform for Logistics Integrated Freight Transport |
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