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| UPNZ | Union Pacific Railroad | |
| UPO | Compiled update data (dBASE) | |
| UPO | Unidentified Piles Of Objects | |
| UPO | Unary Painter Operator | |
| UPO | United Planning Organization | |
| UPO | Undergraduate Programs Office | |
| UPO | United Property Owners | |
| UPO | University Programming Office | |
| UPO | University Publications Office | |
| UPO | Uni- Processor Order | |
| UPO | Underground Parking Only | |
| UPO | Ultra Pure Overflow | |
| UPO | University Planning Office | |
| UPO | Undergraduate Program Office | |
| UPO | Universidad Pablo de Olavide | |
| UPO | Union Philharmonic Orchestra | |
| UPO | Uniform Pensioen Overzicht | |
| UPO | Union Pharmaceutique d'Orient | |
| UPO | University Philharmonic Orchestra | |
| UPO | Undergraduate Program | |
| UPO | University Publishing Online | |
| UPO | Uniquely Partially Orderable | |
| UPO | Utilisation Pedagogique de l'Ordinateur | |
| UPO | Units Per Order | |
| UPOC | Universal Point Of Contact |
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