| OPEN | Online Park Enrollment Network | |
| OPEN | One Planet Education Network | |
| OPEN | Online Physical Education Network | |
| OPEN | Open-Car Pleasure and Entertainment Network | |
| OPEN | Olympic and Paralympic Employment Network | |
| OPEN | Open Protocol Enhanced Network | |
| OPEN | Object Oriented Process Environment and Notation | |
| OPEN | Orphan Pets Enjoy Nature | |
| OPEN | Objects, Process, Environment, and Notation | |
| OPEN | Oregon Public Education Network | |
| OPEN | Our Public Engagement Network | |
| OPEN | Organization of Pakistani Entrepreneurs of North | |
| OPENAL | Open Audio Library | |
| OPENCV | Open Source Computer Vision Library | |
| OPENDAP | Open Source Project for Network Data Access Protocol | |
| OPeNDAP | Open-source Project for a Network Data Access Protocol | |
| OPENGL | Open Graphics Library | |
| OPENITP | Open Internet Tools Project | |
| OPENMG | Open Magic Gate | |
| OPENMP | Open Multi Processing | |
| OPENSIA | OPEN / SIA | |
| OPENU | The Open University | |
| OPEP | Osteoporosis Prevention Exercise Protocol | |
| OPEP | Organization of Parent Education Programs | |
| OPEP | Ontario Pesticide Education Program |
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