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Acronyms that contain the term diclofensine 

What does diclofensine mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: diclofensine.

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DICI, DICJ, DICK, Dickkopf, DICL, DICM, DICO, DICOM, DICONSA, DICOR

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What does diclofensine mean?

Diclofensine
Diclofensine (Ro 8-4650) was developed by Hoffmann-La Roche in the 1970s in the search for a new antidepressant. It was found that the (S)-isomer was responsible for activity. Is a stimulant drug which acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and norepinephrine, with affinities (Ki) of 16.8 nM, 15.7 nM, and 51 nM for DAT, NET, and SERT (dopamine, norepinephrine and serotonin transporters), respectively. It was found to be an effective antidepressant in human trials, with relatively few side effects, but was ultimately dropped from clinical development, possibly due to concerns about its abuse potential.Diclofensine is chemically a tetrahydroisoquinoline (THIQ) derivative, as is nomifensine.

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