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Acronyms that contain the term somatic hypermutation
What does somatic hypermutation mean? This page is about the various possible meanings of the acronym, abbreviation, shorthand or slang term: somatic hypermutation.
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What does somatic hypermutation mean?
- Somatic hypermutation
- Somatic hypermutation (or SHM) is a cellular mechanism by which the immune system adapts to the new foreign elements that confront it (e.g. microbes), as seen during class switching. A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements (antigens) and allows the immune system to adapt its response to new threats during the lifetime of an organism. Somatic hypermutation involves a programmed process of mutation affecting the variable regions of immunoglobulin genes. Unlike germline mutation, SHM affects only an organism's individual immune cells, and the mutations are not transmitted to the organism's offspring. Because this mechanism is merely selective and not precisely targeted, somatic hypermutation has been strongly implicated in the development of B-cell lymphomas and many other cancers.
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"somatic hypermutation." Abbreviations.com. STANDS4 LLC, 2024. Web. 20 Sep. 2024. <https://www.abbreviations.com/somatic%20hypermutation>.
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